253043

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1724608..1725228 Replicon chromosome
Accession NZ_CP101940
Organism Salmonella enterica subsp. enterica strain QA-1986 974

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NP448_RS08800 Protein ID WP_001280991.1
Coordinates 1725010..1725228 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NP448_RS08795 Protein ID WP_000344807.1
Coordinates 1724608..1724982 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP448_RS08785 (1719747) 1719747..1720940 + 1194 WP_001039200.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NP448_RS08790 (1720963) 1720963..1724112 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NP448_RS08795 (1724608) 1724608..1724982 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NP448_RS08800 (1725010) 1725010..1725228 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NP448_RS08805 (1725407) 1725407..1725958 + 552 WP_001278792.1 maltose O-acetyltransferase -
NP448_RS08810 (1726075) 1726075..1726545 + 471 WP_000136181.1 YlaC family protein -
NP448_RS08815 (1726601) 1726601..1726741 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NP448_RS08820 (1726747) 1726747..1727007 - 261 WP_000801421.1 type B 50S ribosomal protein L31 -
NP448_RS08825 (1727232) 1727232..1728782 + 1551 WP_000213145.1 EAL domain-containing protein -
NP448_RS08835 (1729013) 1729013..1729402 + 390 WP_000961285.1 MGMT family protein -
NP448_RS08840 (1729435) 1729435..1730004 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T253043 WP_001280991.1 NZ_CP101940:1725010-1725228 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT253043 WP_000344807.1 NZ_CP101940:1724608-1724982 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References