Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2865811..2866415 Replicon chromosome
Accession NC_015578
Organism Treponema primitia ZAS-2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag TREPR_RS12460 Protein ID WP_015708677.1
Coordinates 2866071..2866415 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag TREPR_RS12455 Protein ID WP_169313426.1
Coordinates 2865811..2866065 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TREPR_RS12430 2861257..2861931 + 675 WP_174269890.1 ABC transporter ATP-binding protein -
TREPR_RS12435 2861924..2863117 + 1194 WP_041611187.1 ABC transporter permease -
TREPR_RS12440 2863129..2864361 - 1233 WP_015708673.1 cation:dicarboxylase symporter family transporter -
TREPR_RS12445 2864418..2865020 + 603 WP_015708674.1 orotate phosphoribosyltransferase -
TREPR_RS12450 2865028..2865732 + 705 WP_015708675.1 HAD-IA family hydrolase -
TREPR_RS12455 2865811..2866065 + 255 WP_169313426.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
TREPR_RS12460 2866071..2866415 + 345 WP_015708677.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
TREPR_RS12465 2866507..2868948 - 2442 WP_041611188.1 tetratricopeptide repeat protein -
TREPR_RS12470 2868950..2870872 - 1923 WP_015708678.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-104)

Antitoxin

SpoVT-AbrB domain

(9-52)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12844.76 Da        Isoelectric Point: 6.2452

>T25304 WP_015708677.1 NC_015578:2866071-2866415 [Treponema primitia ZAS-2]
VPTQGDIIKINLDPKKGYEQMGYRPYICLSNKLISDYANIAVFAPISNTKRQYPLYIPLKGIKTTGVVLLDQLVTIDYAA
RQFQYTETVSPGFLRDLLNTVVLVFQNNQDADGE

Download         Length: 345 bp

>T25304 NC_015578:2866071-2866415 [Treponema primitia ZAS-2]
GTGCCCACCCAGGGTGATATAATTAAAATAAACCTGGATCCGAAAAAGGGATACGAACAAATGGGGTATCGCCCTTATAT
TTGTCTGAGCAACAAGTTGATAAGCGACTATGCAAATATCGCGGTCTTTGCCCCTATATCAAATACCAAGCGCCAATACC
CTCTGTATATTCCGCTTAAGGGGATCAAGACTACCGGCGTGGTTCTGCTGGATCAACTGGTGACTATTGATTACGCGGCC
CGGCAATTCCAGTATACAGAAACGGTTTCCCCTGGATTTCTGAGGGATTTGCTCAATACCGTGGTACTGGTATTTCAGAA
TAACCAAGACGCAGATGGAGAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9675.00 Da        Isoelectric Point: 5.1667

>AT25304 WP_169313426.1 NC_015578:2865811-2866065 [Treponema primitia ZAS-2]
MNVTSVVSKWGNSQALRLPAEVTRRLELHPNDRVFLELEDNKLTITKVPAPKKGTIEYLFKDYSGESFKTELINPEEALG
EERW

Download         Length: 255 bp

>AT25304 NC_015578:2865811-2866065 [Treponema primitia ZAS-2]
ATGAATGTTACATCGGTCGTTTCAAAATGGGGTAACAGTCAAGCCCTGCGGCTTCCGGCGGAAGTAACGCGCCGTTTGGA
ACTCCATCCTAATGATAGGGTTTTTCTGGAGCTTGAGGATAATAAGCTCACCATAACCAAAGTCCCGGCGCCTAAAAAGG
GGACCATCGAATATCTCTTTAAGGATTATTCAGGGGAATCCTTCAAGACTGAACTGATAAACCCCGAAGAAGCGCTTGGT
GAAGAGCGGTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References