253037

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 561416..562052 Replicon chromosome
Accession NZ_CP101938
Organism Bacillus altitudinis strain BDGP7

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag NP445_RS02765 Protein ID WP_003214169.1
Coordinates 561702..562052 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A267X601
Locus tag NP445_RS02760 Protein ID WP_012008995.1
Coordinates 561416..561697 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP445_RS02740 (NP445_02740) 557562..558167 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
NP445_RS02745 (NP445_02745) 558262..558627 + 366 WP_017366663.1 holo-ACP synthase -
NP445_RS02750 (NP445_02750) 558788..559804 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
NP445_RS02755 (NP445_02755) 559940..561121 + 1182 WP_256689026.1 alanine racemase -
NP445_RS02760 (NP445_02760) 561416..561697 + 282 WP_012008995.1 hypothetical protein Antitoxin
NP445_RS02765 (NP445_02765) 561702..562052 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
NP445_RS02770 (NP445_02770) 562167..562997 + 831 WP_017358395.1 RsbT co-antagonist protein RsbRA -
NP445_RS02775 (NP445_02775) 563002..563370 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
NP445_RS02780 (NP445_02780) 563373..563774 + 402 WP_003214085.1 anti-sigma regulatory factor -
NP445_RS02785 (NP445_02785) 563785..564792 + 1008 WP_061418047.1 PP2C family protein-serine/threonine phosphatase -
NP445_RS02790 (NP445_02790) 564852..565181 + 330 WP_017358393.1 anti-sigma factor antagonist -
NP445_RS02795 (NP445_02795) 565178..565666 + 489 WP_024719203.1 anti-sigma B factor RsbW -
NP445_RS02800 (NP445_02800) 565632..566420 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
NP445_RS02805 (NP445_02805) 566420..567019 + 600 WP_024719202.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T253037 WP_003214169.1 NZ_CP101938:561702-562052 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10894.27 Da        Isoelectric Point: 5.2726

>AT253037 WP_012008995.1 NZ_CP101938:561416-561697 [Bacillus altitudinis]
MSESSATNEMKIRLPETLMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A267X601

References