Detailed information of TA system TA025303

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpIK/MazF(toxin)
• Location: 910205..910787
• Replicon: chromosome
• Accession: NC_015578
• Organism: Treponema primitia ZAS-2

Toxin (Protein)

• Gene name: chpK
• Uniprot ID: F5YKW8
• Locus tag: TREPR_RS04085
• Protein ID: WP_015707021.1
• Coordinates: 910440..910787 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: chpI
• Uniprot ID: -
• Locus tag: TREPR_RS04080
• Protein ID: WP_041611006.1
• Coordinates: 910205..910453 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TREPR_RS04070	905348..905765	+	418	Protein_806	aspartyl protease family protein	-
TREPR_RS04075	906242..909742	+	3501	WP_169313403.1	InlB B-repeat-containing protein	-
TREPR_RS04080	910205..910453	+	249	WP_041611006.1	hypothetical protein	Antitoxin
TREPR_RS04085	910440..910787	+	348	WP_015707021.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
TREPR_RS04090	910760..911206	+	447	WP_081468631.1	transposase	-
TREPR_RS04095	911515..911805	+	291	WP_041611431.1	nucleotidyltransferase domain-containing protein	-
TREPR_RS18795	911792..912013	+	222	WP_015707024.1	hypothetical protein	-
TREPR_RS18800	912020..912235	+	216	WP_201765777.1	DUF86 domain-containing protein	-
TREPR_RS04105	912552..913157	+	606	WP_201765763.1	6-carboxytetrahydropterin synthase	-
TREPR_RS04110	913250..914695	+	1446	WP_015707027.1	Trk system potassium transport protein TrkA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-108)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13085.54 Da
• Isoelectric Point: 9.7981

>T25303 WP_015707021.1 NC_015578:910440-910787 [Treponema primitia ZAS-2]
MIRGEIWWIDYGIPYGNEPGYRRPVIIIQNDLFNASKINTTVVIPLSTNLLLADVPGNIILKKDDSKLKKNSVILLSQIG
VIDKERLIEKISKINKEVMREIENSILFVLGIKLI

Nucleotide

• Length: 348 bp

>T25303 NC_015578:910440-910787 [Treponema primitia ZAS-2]
ATGATACGTGGTGAAATATGGTGGATTGATTATGGTATTCCCTATGGCAACGAACCTGGATACAGACGGCCTGTTATAAT
AATACAAAATGATCTTTTTAACGCCAGTAAAATCAATACAACTGTTGTCATACCATTATCAACAAATTTATTATTGGCTG
ATGTTCCTGGGAATATAATTCTTAAAAAAGACGATTCAAAATTAAAGAAAAATTCTGTAATACTATTATCGCAAATAGGT
GTTATTGATAAAGAACGTCTTATAGAAAAAATATCAAAAATCAATAAAGAAGTAATGAGAGAAATAGAAAATAGTATACT
ATTTGTACTTGGAATAAAGTTAATATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9571.96 Da
• Isoelectric Point: 5.1425

>AT25303 WP_041611006.1 NC_015578:910205-910453 [Treponema primitia ZAS-2]
MKTAISLPDVLYKRAEETASYMGVPRSKLFAMALEEFVVRHNGKMITEKINEVYDKIDQKEFEPYLNATLEAQRDLTKND
TW

Nucleotide

• Length: 249 bp

>AT25303 NC_015578:910205-910453 [Treponema primitia ZAS-2]
ATGAAAACAGCAATATCTCTTCCGGATGTGTTATATAAACGGGCCGAAGAAACGGCTTCATACATGGGTGTTCCTCGAAG
CAAATTATTTGCGATGGCTTTGGAAGAATTTGTTGTCAGGCATAATGGAAAAATGATAACGGAAAAAATCAATGAAGTTT
ATGACAAAATTGATCAAAAAGAATTCGAACCATATTTAAATGCAACACTTGAAGCTCAAAGGGATTTAACCAAAAATGAT
ACGTGGTGA

Structures

Toxin

• AlphaFold DB: F5YKW8