Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1320755..1321671 Replicon chromosome
Accession NZ_CP101936
Organism Bacillus subtilis subsp. subtilis strain BGSC 10A5

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag NP434_RS06985 Protein ID WP_089172519.1
Coordinates 1320925..1321671 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag NP434_RS06980 Protein ID WP_003232646.1
Coordinates 1320755..1320925 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP434_RS06940 (NP434_06940) 1316472..1316801 + 330 WP_256683382.1 XkdW family protein -
NP434_RS06945 (NP434_06945) 1316798..1316962 + 165 WP_014479563.1 XkdX family protein -
NP434_RS06950 (NP434_06950) 1317006..1317845 + 840 WP_256683383.1 phage-like element PBSX protein XepA -
NP434_RS06955 (NP434_06955) 1317898..1318167 + 270 WP_015252265.1 hemolysin XhlA family protein -
NP434_RS06960 (NP434_06960) 1318180..1318443 + 264 WP_014479566.1 phage holin -
NP434_RS06965 (NP434_06965) 1318456..1319352 + 897 WP_181217006.1 N-acetylmuramoyl-L-alanine amidase -
NP434_RS06970 (NP434_06970) 1319429..1320520 + 1092 WP_181217007.1 acyltransferase family protein -
NP434_RS06975 (NP434_06975) 1320517..1320669 - 153 WP_181217008.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
NP434_RS06980 (NP434_06980) 1320755..1320925 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
NP434_RS06985 (NP434_06985) 1320925..1321671 - 747 WP_089172519.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
NP434_RS06990 (NP434_06990) 1321781..1322782 - 1002 WP_003232642.1 inorganic phosphate transporter -
NP434_RS06995 (NP434_06995) 1322795..1323412 - 618 WP_003218470.1 DUF47 domain-containing protein -
NP434_RS07000 (NP434_07000) 1323688..1325004 - 1317 WP_256683384.1 serine/threonine exchanger -
NP434_RS07005 (NP434_07005) 1325393..1326343 + 951 WP_014476561.1 ring-cleaving dioxygenase -
NP434_RS07010 (NP434_07010) 1326453..1326554 + 102 Protein_1317 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29121.60 Da        Isoelectric Point: 4.6191

>T253019 WP_089172519.1 NZ_CP101936:c1321671-1320925 [Bacillus subtilis subsp. subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMFAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT253019 WP_003232646.1 NZ_CP101936:c1320925-1320755 [Bacillus subtilis subsp. subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References