253011

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1320754..1321670 Replicon chromosome
Accession NZ_CP101930
Organism Bacillus subtilis strain BGSC 10A5

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag NP433_RS06985 Protein ID WP_089172519.1
Coordinates 1320924..1321670 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag NP433_RS06980 Protein ID WP_003232646.1
Coordinates 1320754..1320924 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP433_RS06940 (NP433_06940) 1316471..1316800 + 330 WP_256683382.1 XkdW family protein -
NP433_RS06945 (NP433_06945) 1316797..1316961 + 165 WP_014479563.1 XkdX family protein -
NP433_RS06950 (NP433_06950) 1317005..1317844 + 840 WP_256683383.1 phage-like element PBSX protein XepA -
NP433_RS06955 (NP433_06955) 1317897..1318166 + 270 WP_015252265.1 hemolysin XhlA family protein -
NP433_RS06960 (NP433_06960) 1318179..1318442 + 264 WP_014479566.1 phage holin -
NP433_RS06965 (NP433_06965) 1318455..1319351 + 897 WP_181217006.1 N-acetylmuramoyl-L-alanine amidase -
NP433_RS06970 (NP433_06970) 1319428..1320519 + 1092 WP_181217007.1 acyltransferase family protein -
NP433_RS06975 (NP433_06975) 1320516..1320668 - 153 WP_181217008.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
NP433_RS06980 (NP433_06980) 1320754..1320924 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
NP433_RS06985 (NP433_06985) 1320924..1321670 - 747 WP_089172519.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
NP433_RS06990 (NP433_06990) 1321780..1322781 - 1002 WP_003232642.1 inorganic phosphate transporter -
NP433_RS06995 (NP433_06995) 1322794..1323411 - 618 WP_003218470.1 DUF47 domain-containing protein -
NP433_RS07000 (NP433_07000) 1323687..1325003 - 1317 WP_256683384.1 serine/threonine exchanger -
NP433_RS07005 (NP433_07005) 1325392..1326342 + 951 WP_014476561.1 ring-cleaving dioxygenase -
NP433_RS07010 (NP433_07010) 1326452..1326553 + 102 Protein_1317 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29121.60 Da        Isoelectric Point: 4.6191

>T253011 WP_089172519.1 NZ_CP101930:c1321670-1320924 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMFAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT253011 WP_003232646.1 NZ_CP101930:c1320924-1320754 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References