Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3738230..3738848 Replicon chromosome
Accession NZ_CP101925
Organism Escherichia coli strain Seattle 1946

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NP429_RS18120 Protein ID WP_001291435.1
Coordinates 3738630..3738848 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NP429_RS18115 Protein ID WP_000344800.1
Coordinates 3738230..3738604 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP429_RS18105 (3733320) 3733320..3734513 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NP429_RS18110 (3734536) 3734536..3737685 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NP429_RS18115 (3738230) 3738230..3738604 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NP429_RS18120 (3738630) 3738630..3738848 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NP429_RS18125 (3739021) 3739021..3739572 + 552 WP_000102539.1 maltose O-acetyltransferase -
NP429_RS18130 (3739688) 3739688..3740158 + 471 WP_001304825.1 YlaC family protein -
NP429_RS18135 (3740322) 3740322..3741872 + 1551 WP_001528761.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NP429_RS18140 (3741914) 3741914..3742267 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NP429_RS18150 (3742646) 3742646..3742957 + 312 WP_000409908.1 MGMT family protein -
NP429_RS18155 (3742988) 3742988..3743560 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T253000 WP_001291435.1 NZ_CP101925:3738630-3738848 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT253000 WP_000344800.1 NZ_CP101925:3738230-3738604 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References