Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2557251..2558839 Replicon chromosome
Accession NZ_CP101925
Organism Escherichia coli strain Seattle 1946

Toxin (Protein)


Gene name hipA Uniprot ID A0A1L1KDK2
Locus tag NP429_RS12195 Protein ID WP_001125431.1
Coordinates 2557517..2558839 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V0VAH2
Locus tag NP429_RS12190 Protein ID WP_001304368.1
Coordinates 2557251..2557517 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP429_RS12175 (2553619) 2553619..2555070 + 1452 WP_000854660.1 tagaturonate reductase -
NP429_RS12180 (2555267) 2555267..2556181 + 915 WP_001443133.1 bestrophin family protein -
NP429_RS12185 (2556185) 2556185..2556943 - 759 WP_001286540.1 trans-aconitate 2-methyltransferase -
NP429_RS12190 (2557251) 2557251..2557517 + 267 WP_001304368.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NP429_RS12195 (2557517) 2557517..2558839 + 1323 WP_001125431.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
NP429_RS12200 (2559149) 2559149..2559556 - 408 Protein_2390 acetylxylan esterase -
NP429_RS12205 (2559559) 2559559..2560140 - 582 Protein_2391 LysR family transcriptional regulator -
NP429_RS12210 (2560289) 2560289..2561071 + 783 WP_001221834.1 SDR family oxidoreductase -
NP429_RS12215 (2561315) 2561315..2561422 - 108 Protein_2393 hypothetical protein -
NP429_RS12220 (2561847) 2561847..2562410 + 564 WP_001327671.1 type 1 fimbrial major subunit FimA -
NP429_RS12225 (2562772) 2562772..2563482 + 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49310.02 Da        Isoelectric Point: 8.6972

>T252996 WP_001125431.1 NZ_CP101925:2557517-2558839 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKNSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9957.31 Da        Isoelectric Point: 4.9632

>AT252996 WP_001304368.1 NZ_CP101925:2557251-2557517 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L1KDK2

Antitoxin

Source ID Structure
AlphaFold DB V0VAH2

References