Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 46924..47715 Replicon chromosome
Accession NZ_CP101925
Organism Escherichia coli strain Seattle 1946

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag NP429_RS00235 Protein ID WP_000691791.1
Coordinates 46924..47349 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3L1KVZ6
Locus tag NP429_RS00240 Protein ID WP_000939437.1
Coordinates 47380..47715 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP429_RS00210 (42590) 42590..43087 - 498 WP_000509808.1 hypothetical protein -
NP429_RS00215 (43769) 43769..44155 - 387 WP_001270938.1 DUF2441 domain-containing protein -
NP429_RS00220 (44778) 44778..45509 - 732 WP_001216639.1 retron system putative HNH endonuclease -
NP429_RS00225 (45506) 45506..45727 - 222 WP_125112077.1 hypothetical protein -
NP429_RS00230 (45712) 45712..46903 - 1192 Protein_45 AAA family ATPase -
NP429_RS00235 (46924) 46924..47349 - 426 WP_000691791.1 TA system toxin CbtA family protein Toxin
NP429_RS00240 (47380) 47380..47715 - 336 WP_000939437.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NP429_RS00245 (47715) 47715..48188 - 474 WP_001292742.1 DNA repair protein RadC -
NP429_RS00250 (48218) 48218..49032 - 815 Protein_49 DUF945 domain-containing protein -
NP429_RS00255 (49268) 49268..50221 - 954 WP_000290406.1 hypothetical protein -
NP429_RS00260 (50814) 50814..51428 + 615 WP_000772910.1 inovirus Gp2 family protein -
NP429_RS00265 (51546) 51546..51764 + 219 WP_000070772.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 44778..68709 23931


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16490.11 Da        Isoelectric Point: 10.2376

>T252985 WP_000691791.1 NZ_CP101925:c47349-46924 [Escherichia coli]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVNAVNFLVEKYELVRIDRKGF
SWQEQTPYLRAVDILRARQATGLRIQCKNTNIISRMADSRHDKRLYQRTFKACKRCYYTKT

Download         Length: 426 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12556.56 Da        Isoelectric Point: 7.6977

>AT252985 WP_000939437.1 NZ_CP101925:c47715-47380 [Escherichia coli]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSPCQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3L1KVZ6

References