Detailed information of TA system TA025298

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 4492522..4493055
• Replicon: chromosome
• Accession: NC_015576
• Organism: Mycobacterium sp. JDM601

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JDM601_RS22565
• Protein ID: WP_081465688.1
• Coordinates: 4492810..4493055 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: F5YUZ3
• Locus tag: JDM601_RS20975
• Protein ID: WP_013831127.1
• Coordinates: 4492522..4492773 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JDM601_RS20955	4489099..4489569	+	471	WP_041320404.1	SRPBCC family protein	-
JDM601_RS20960	4489664..4490293	+	630	WP_013831124.1	TetR/AcrR family transcriptional regulator	-
JDM601_RS20965	4490253..4491197	-	945	WP_041319167.1	SDR family NAD(P)-dependent oxidoreductase	-
JDM601_RS20970	4491249..4492475	+	1227	WP_013831126.1	cytochrome P450	-
JDM601_RS20975	4492522..4492773	+	252	WP_013831127.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
JDM601_RS22565	4492810..4493055	+	246	WP_081465688.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JDM601_RS20980	4493076..4493579	-	504	WP_041319170.1	SRPBCC family protein	-
JDM601_RS20985	4493615..4495378	-	1764	WP_041320407.1	amidohydrolase family protein	-
JDM601_RS20990	4495461..4496054	+	594	WP_013831130.1	TetR/AcrR family transcriptional regulator	-
JDM601_RS20995	4496051..4497190	+	1140	WP_013831131.1	epoxide hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-76)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9502.76 Da
• Isoelectric Point: 6.7164

>T25298 WP_081465688.1 NC_015576:4492810-4493055 [Mycolicibacter sinensis]
IWDYTADRWGVDQAEEYLPELQYAIERLAAKPRIGRTCDEIRPGYRKLSAGSHTLFYRLTADAVVDVVRVLHQRMDTERH
L

Nucleotide

• Length: 246 bp

>T25298 NC_015576:4492810-4493055 [Mycolicibacter sinensis]
ATCTGGGATTACACCGCGGACCGCTGGGGCGTCGACCAGGCCGAAGAGTACCTGCCCGAGCTCCAGTACGCGATCGAACG
TCTTGCCGCGAAGCCACGGATCGGCCGAACCTGTGACGAGATCCGACCCGGCTATCGCAAACTATCGGCCGGATCCCACA
CGCTGTTCTATCGACTGACTGCCGACGCCGTCGTCGACGTAGTTCGGGTCTTGCACCAACGGATGGACACCGAGCGGCAT
CTCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9551.60 Da
• Isoelectric Point: 5.1634

>AT25298 WP_013831127.1 NC_015576:4492522-4492773 [Mycolicibacter sinensis]
MGKNTSFVLDDHYQAFIDQEIAAGRYRSVSEVIRSALRLLEDREAQLRALRTALEDGERSGESTPFDFDAFLDRKRTDAS
RIR

Nucleotide

• Length: 252 bp

>AT25298 NC_015576:4492522-4492773 [Mycolicibacter sinensis]
ATGGGCAAGAACACGTCCTTCGTGCTCGACGATCATTACCAGGCCTTCATCGACCAGGAGATCGCAGCCGGACGCTACCG
ATCGGTCAGCGAGGTTATCCGCTCGGCATTGCGGCTGCTGGAGGATCGCGAAGCACAACTGCGGGCCCTGCGCACCGCCC
TCGAGGACGGTGAACGTAGCGGCGAGTCGACGCCGTTTGACTTCGATGCCTTCCTCGACCGCAAGCGGACGGATGCGTCG
CGTATCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I9YEV9