Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3369544..3370162 Replicon chromosome
Accession NZ_CP101922
Organism Escherichia coli strain JCC-EE 7

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NP442_RS16490 Protein ID WP_001291435.1
Coordinates 3369944..3370162 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NP442_RS16485 Protein ID WP_000344800.1
Coordinates 3369544..3369918 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP442_RS16475 (3364633) 3364633..3365826 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NP442_RS16480 (3365849) 3365849..3368998 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NP442_RS16485 (3369544) 3369544..3369918 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NP442_RS16490 (3369944) 3369944..3370162 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NP442_RS16495 (3370334) 3370334..3370885 + 552 WP_000102564.1 maltose O-acetyltransferase -
NP442_RS16500 (3371001) 3371001..3371471 + 471 WP_000136192.1 YlaC family protein -
NP442_RS16505 (3371635) 3371635..3373185 + 1551 WP_001727568.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NP442_RS16510 (3373227) 3373227..3373580 - 354 WP_097496338.1 DUF1428 family protein -
NP442_RS16520 (3373959) 3373959..3374270 + 312 WP_000409911.1 MGMT family protein -
NP442_RS16525 (3374301) 3374301..3374873 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T252979 WP_001291435.1 NZ_CP101922:3369944-3370162 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT252979 WP_000344800.1 NZ_CP101922:3369544-3369918 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References