Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2374106..2374744 Replicon chromosome
Accession NZ_CP101922
Organism Escherichia coli strain JCC-EE 7

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NP442_RS11515 Protein ID WP_000813794.1
Coordinates 2374568..2374744 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NP442_RS11510 Protein ID WP_001270286.1
Coordinates 2374106..2374522 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP442_RS11490 (2369258) 2369258..2370199 - 942 WP_001251313.1 ABC transporter permease -
NP442_RS11495 (2370200) 2370200..2371213 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
NP442_RS11500 (2371231) 2371231..2372376 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NP442_RS11505 (2372621) 2372621..2374027 - 1407 WP_001735217.1 PLP-dependent aminotransferase family protein -
NP442_RS11510 (2374106) 2374106..2374522 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NP442_RS11515 (2374568) 2374568..2374744 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NP442_RS11520 (2374966) 2374966..2375196 + 231 WP_000494244.1 YncJ family protein -
NP442_RS11525 (2375288) 2375288..2377249 - 1962 WP_098717239.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NP442_RS11530 (2377322) 2377322..2377858 - 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
NP442_RS11535 (2377950) 2377950..2379125 + 1176 WP_252356393.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T252978 WP_000813794.1 NZ_CP101922:c2374744-2374568 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT252978 WP_001270286.1 NZ_CP101922:c2374522-2374106 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References