Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 866447..867101 Replicon chromosome
Accession NZ_CP101922
Organism Escherichia coli strain JCC-EE 7

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NP442_RS04245 Protein ID WP_000244781.1
Coordinates 866694..867101 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NP442_RS04240 Protein ID WP_000354046.1
Coordinates 866447..866713 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP442_RS04220 (862535) 862535..863968 - 1434 WP_001394742.1 6-phospho-beta-glucosidase BglA -
NP442_RS04225 (864013) 864013..864324 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
NP442_RS04230 (864488) 864488..865147 + 660 WP_000250274.1 hemolysin III family protein -
NP442_RS04235 (865224) 865224..866204 - 981 WP_000886087.1 tRNA-modifying protein YgfZ -
NP442_RS04240 (866447) 866447..866713 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NP442_RS04245 (866694) 866694..867101 + 408 WP_000244781.1 protein YgfX Toxin
NP442_RS04250 (867141) 867141..867662 - 522 WP_001055874.1 flavodoxin FldB -
NP442_RS04255 (867774) 867774..868670 + 897 WP_000806650.1 site-specific tyrosine recombinase XerD -
NP442_RS04260 (868695) 868695..869405 + 711 WP_000715222.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NP442_RS04265 (869411) 869411..871144 + 1734 WP_000813233.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T252970 WP_000244781.1 NZ_CP101922:866694-867101 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT252970 WP_000354046.1 NZ_CP101922:866447-866713 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References