25297

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4336368..4336932 Replicon chromosome
Accession NC_015576
Organism Mycobacterium sp. JDM601

Toxin (Protein)


Gene name mazF Uniprot ID F5YTQ4
Locus tag JDM601_RS20405 Protein ID WP_013831006.1
Coordinates 4336585..4336932 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID F5YTQ3
Locus tag JDM601_RS20400 Protein ID WP_013831005.1
Coordinates 4336368..4336598 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JDM601_RS20380 4333217..4333786 + 570 WP_049792962.1 bacterial proteasome activator family protein -
JDM601_RS20385 4333793..4334596 + 804 WP_013831002.1 ABC transporter ATP-binding protein -
JDM601_RS20390 4334593..4335510 + 918 WP_013831003.1 glycosyltransferase family 2 protein -
JDM601_RS20395 4335507..4336337 + 831 WP_013831004.1 ABC transporter permease -
JDM601_RS20400 4336368..4336598 + 231 WP_013831005.1 ribbon-helix-helix domain-containing protein Antitoxin
JDM601_RS20405 4336585..4336932 + 348 WP_013831006.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JDM601_RS20410 4336962..4338068 - 1107 WP_013831007.1 mandelate racemase/muconate lactonizing enzyme family protein -
JDM601_RS20415 4338102..4338515 + 414 WP_013831008.1 GtrA family protein -
JDM601_RS20420 4338619..4338864 + 246 WP_013831009.1 hypothetical protein -
JDM601_RS20425 4338849..4339253 + 405 WP_013831010.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12593.36 Da        Isoelectric Point: 10.3987

>T25297 WP_013831006.1 NC_015576:4336585-4336932 [Mycolicibacter sinensis]
MRRGDIWQVDFDPTRGSEANKYRPAVVVSNDRANATAGRLGRGVVTVVPVTSNTATVYPFQVLLPATSTGLAVDSKAQAE
QIRSVAVERLQRRIGRLPAIELTQLDEALRLHLDL

Download         Length: 348 bp

>T25297 NC_015576:4336585-4336932 [Mycolicibacter sinensis]
ATGCGCCGCGGTGACATCTGGCAGGTCGACTTCGACCCGACCCGGGGAAGCGAAGCGAACAAGTACCGCCCGGCCGTCGT
CGTCAGCAACGACCGGGCCAATGCAACGGCCGGCCGACTCGGTCGCGGCGTGGTGACCGTCGTCCCGGTGACCAGCAACA
CCGCTACTGTCTACCCGTTCCAGGTGCTGTTGCCGGCCACCTCCACCGGCCTGGCCGTCGATTCGAAAGCACAAGCCGAA
CAGATCAGGTCGGTTGCCGTCGAACGTCTGCAACGGCGAATCGGCCGCCTCCCGGCGATCGAACTCACCCAACTCGACGA
GGCGCTGCGACTGCACCTCGACTTGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8411.17 Da        Isoelectric Point: 4.0424

>AT25297 WP_013831005.1 NC_015576:4336368-4336598 [Mycolicibacter sinensis]
MKLSISLSAEDVEALDAYAQRTGLPSRSAAVQHAIRMLRYPTLEDDYADAWAQWSADGEDQVWDRATDDGAVDAPR

Download         Length: 231 bp

>AT25297 NC_015576:4336368-4336598 [Mycolicibacter sinensis]
ATGAAGTTGAGTATCAGCCTTTCCGCCGAGGATGTCGAGGCTCTGGACGCCTACGCGCAACGCACGGGTTTGCCGTCCCG
TTCGGCGGCCGTCCAGCATGCGATTCGGATGCTGCGCTACCCCACCCTCGAAGACGACTACGCCGACGCTTGGGCGCAGT
GGTCGGCCGACGGTGAGGATCAGGTTTGGGACCGGGCCACCGACGACGGGGCCGTCGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I9YEP4

Antitoxin

Source ID Structure
AlphaFold DB A0A7I9YF13

References