Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 788954..789786 Replicon chromosome
Accession NZ_CP101922
Organism Escherichia coli strain JCC-EE 7

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag NP442_RS03840 Protein ID WP_000854765.1
Coordinates 788954..789328 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag NP442_RS03845 Protein ID WP_001295723.1
Coordinates 789418..789786 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP442_RS03820 (786746) 786746..787966 + 1221 WP_001735713.1 capsular biosynthesis protein -
NP442_RS03825 (787992) 787992..788222 - 231 Protein_751 hypothetical protein -
NP442_RS03830 (788328) 788328..788504 - 177 WP_000839288.1 DUF957 domain-containing protein -
NP442_RS03835 (788521) 788521..788957 - 437 Protein_753 DUF5983 family protein -
NP442_RS03840 (788954) 788954..789328 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
NP442_RS03845 (789418) 789418..789786 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NP442_RS03850 (789949) 789949..790170 - 222 WP_001735710.1 DUF987 domain-containing protein -
NP442_RS03855 (790239) 790239..790715 - 477 WP_001186725.1 RadC family protein -
NP442_RS03860 (790731) 790731..791216 - 486 WP_001735709.1 antirestriction protein -
NP442_RS03865 (791271) 791271..792089 - 819 WP_074481115.1 DUF932 domain-containing protein -
NP442_RS03870 (792207) 792207..792402 - 196 Protein_760 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T252969 WP_000854765.1 NZ_CP101922:c789328-788954 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT252969 WP_001295723.1 NZ_CP101922:c789786-789418 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References