Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4291271..4291768 Replicon chromosome
Accession NZ_CP101921
Organism Escherichia coli strain QA-1986 83

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NP438_RS20765 Protein ID WP_001173343.1
Coordinates 4291271..4291444 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID -
Locus tag NP438_RS20770 Protein ID WP_071988580.1
Coordinates 4291472..4291768 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP438_RS20755 (4287941) 4287941..4289398 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
NP438_RS20760 (4289635) 4289635..4291152 + 1518 WP_001295087.1 lysine--tRNA ligase -
NP438_RS20765 (4291271) 4291271..4291444 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NP438_RS20770 (4291472) 4291472..4291768 - 297 WP_071988580.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NP438_RS20775 (4291995) 4291995..4292267 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NP438_RS20780 (4292480) 4292480..4296409 - 3930 WP_046201569.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4291271..4316437 25166


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T252964 WP_001173343.1 NZ_CP101921:c4291444-4291271 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11482.00 Da        Isoelectric Point: 4.1705

>AT252964 WP_071988580.1 NZ_CP101921:c4291768-4291472 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSTIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure

References