Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4188171..4188766 Replicon chromosome
Accession NZ_CP101921
Organism Escherichia coli strain QA-1986 83

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NP438_RS20245 Protein ID WP_000239579.1
Coordinates 4188171..4188521 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2J1DIF8
Locus tag NP438_RS20250 Protein ID WP_001223209.1
Coordinates 4188515..4188766 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP438_RS20225 (4183617) 4183617..4184639 - 1023 WP_024251350.1 ABC transporter permease -
NP438_RS20230 (4184653) 4184653..4186155 - 1503 WP_000205810.1 sugar ABC transporter ATP-binding protein -
NP438_RS20235 (4186295) 4186295..4187251 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NP438_RS20240 (4187561) 4187561..4188091 + 531 WP_000055075.1 inorganic diphosphatase -
NP438_RS20245 (4188171) 4188171..4188521 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NP438_RS20250 (4188515) 4188515..4188766 - 252 WP_001223209.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NP438_RS20255 (4188978) 4188978..4189319 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NP438_RS20260 (4189322) 4189322..4193101 - 3780 WP_000060896.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T252963 WP_000239579.1 NZ_CP101921:c4188521-4188171 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9301.61 Da        Isoelectric Point: 4.4201

>AT252963 WP_001223209.1 NZ_CP101921:c4188766-4188515 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWSKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J1DIF8

References