252962

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4137346..4138681 Replicon chromosome
Accession NZ_CP101921
Organism Escherichia coli strain QA-1986 83

Toxin (Protein)


Gene name sanaT Uniprot ID F4VMR9
Locus tag NP438_RS20020 Protein ID WP_000342497.1
Coordinates 4137346..4138293 (-) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A228Z6F8
Locus tag NP438_RS20025 Protein ID WP_000152739.1
Coordinates 4138286..4138681 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP438_RS19990 (4133199) 4133199..4133915 + 717 WP_001295734.1 N-acetylneuraminic acid outer membrane channel NanC -
NP438_RS19995 (4133935) 4133935..4135041 + 1107 WP_001044128.1 N-acetylneuraminate epimerase -
NP438_RS20000 (4135106) 4135106..4136086 + 981 WP_001366032.1 sialate O-acetylesterase -
NP438_RS20005 (4136094) 4136094..4136744 - 651 WP_001037970.1 HNH endonuclease -
NP438_RS20010 (4136881) 4136881..4137024 + 144 Protein_3916 HNH endonuclease -
NP438_RS20015 (4137123) 4137123..4137308 + 186 WP_000066585.1 hypothetical protein -
NP438_RS20020 (4137346) 4137346..4138293 - 948 WP_000342497.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NP438_RS20025 (4138286) 4138286..4138681 - 396 WP_000152739.1 DUF6088 family protein Antitoxin
NP438_RS20030 (4138751) 4138751..4139584 - 834 WP_001192741.1 DUF4942 domain-containing protein -
NP438_RS20035 (4139890) 4139890..4141446 + 1557 WP_000202816.1 type I restriction-modification system subunit M -
NP438_RS20040 (4141443) 4141443..4142609 + 1167 WP_001293040.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4131141..4142609 11468


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-303)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 35588.79 Da        Isoelectric Point: 4.9737

>T252962 WP_000342497.1 NZ_CP101921:c4138293-4137346 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA

Download         Length: 948 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14605.90 Da        Isoelectric Point: 11.6915

>AT252962 WP_000152739.1 NZ_CP101921:c4138681-4138286 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRDLVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5BAQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A228Z6F8

References