252960

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3535997..3536615 Replicon chromosome
Accession NZ_CP101921
Organism Escherichia coli strain QA-1986 83

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NP438_RS17195 Protein ID WP_001291435.1
Coordinates 3536397..3536615 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NP438_RS17190 Protein ID WP_000344800.1
Coordinates 3535997..3536371 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP438_RS17180 (3531086) 3531086..3532279 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NP438_RS17185 (3532302) 3532302..3535451 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NP438_RS17190 (3535997) 3535997..3536371 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NP438_RS17195 (3536397) 3536397..3536615 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NP438_RS17200 (3536786) 3536786..3537337 + 552 WP_000102556.1 maltose O-acetyltransferase -
NP438_RS17205 (3537453) 3537453..3537923 + 471 WP_000136192.1 YlaC family protein -
NP438_RS17210 (3538087) 3538087..3539637 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NP438_RS17215 (3539679) 3539679..3540032 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NP438_RS17225 (3540411) 3540411..3540722 + 312 WP_000409911.1 MGMT family protein -
NP438_RS17230 (3540753) 3540753..3541325 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T252960 WP_001291435.1 NZ_CP101921:3536397-3536615 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT252960 WP_000344800.1 NZ_CP101921:3535997-3536371 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References