Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-VapB
Location 3940913..3941576 Replicon chromosome
Accession NC_015576
Organism Mycobacterium sp. JDM601

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JDM601_RS18620 Protein ID WP_041318859.1
Coordinates 3941148..3941576 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JDM601_RS22395 Protein ID WP_081465574.1
Coordinates 3940913..3941161 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JDM601_RS18600 3936812..3937960 + 1149 WP_041320244.1 prolyl oligopeptidase family serine peptidase -
JDM601_RS18605 3937965..3939155 + 1191 WP_013830648.1 pyridoxal phosphate-dependent aminotransferase -
JDM601_RS18610 3939201..3939602 + 402 WP_013830649.1 heme-binding protein -
JDM601_RS18615 3939610..3940884 + 1275 WP_013830650.1 hypothetical protein -
JDM601_RS22395 3940913..3941161 + 249 WP_081465574.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JDM601_RS18620 3941148..3941576 + 429 WP_041318859.1 type II toxin-antitoxin system VapC family toxin Toxin
JDM601_RS18625 3941681..3944281 - 2601 WP_202945076.1 NAD-dependent epimerase/dehydratase family protein -
JDM601_RS18630 3944415..3945323 - 909 WP_202945077.1 hypothetical protein -
JDM601_RS21900 3945516..3946199 + 684 WP_049792941.1 TetR/AcrR family transcriptional regulator C-terminal ligand-binding domain-containing protein -
JDM601_RS18640 3946337..3946477 + 141 Protein_3730 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15780.85 Da        Isoelectric Point: 7.3529

>T25296 WP_041318859.1 NC_015576:3941148-3941576 [Mycolicibacter sinensis]
MLLFDVNVCVYAIRKDTPDHAGYRSWVNETLNGDEPVGISDLVLSGVIRVITNHRIFEQPSTTQQALDSCRALRSGPAAV
PLRPGERHWAIFESLCRDTSAKGNAVPDAYHAALAIENGATWITTDRGFARFPGLRWRHPLQ

Download         Length: 429 bp

>T25296 NC_015576:3941148-3941576 [Mycolicibacter sinensis]
ATGCTGCTGTTTGATGTCAACGTCTGCGTTTACGCCATCCGCAAGGACACTCCCGACCACGCCGGTTATCGCTCCTGGGT
CAACGAAACGCTCAACGGGGACGAGCCCGTCGGGATAAGCGATCTCGTACTGTCGGGCGTTATCCGGGTCATCACCAACC
ATCGGATCTTCGAACAGCCCAGTACAACGCAGCAAGCTCTGGACTCTTGCCGAGCGCTCCGTTCAGGTCCTGCCGCGGTC
CCGCTGCGACCGGGCGAACGGCACTGGGCGATCTTCGAGTCGCTGTGCCGTGACACGAGCGCGAAGGGCAACGCCGTTCC
CGACGCTTATCACGCCGCTCTGGCTATCGAAAACGGTGCGACCTGGATCACCACCGATCGCGGTTTCGCTCGCTTTCCCG
GACTACGCTGGCGCCACCCGTTGCAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8785.95 Da        Isoelectric Point: 6.2146

>AT25296 WP_081465574.1 NC_015576:3940913-3941161 [Mycolicibacter sinensis]
MRTTINIDDHLLAEAKVVAARTSRPLGAIVDDALRAFLRRDTGSKARQVFELPTHGHGGLRPGVDLDDKDALAELLGDNA
AV

Download         Length: 249 bp

>AT25296 NC_015576:3940913-3941161 [Mycolicibacter sinensis]
ATGCGCACCACAATCAATATCGACGACCACCTGCTAGCCGAAGCGAAGGTAGTGGCGGCAAGGACGTCGAGGCCGCTCGG
TGCGATCGTGGACGACGCCTTGCGAGCTTTTCTTCGCCGCGATACGGGCTCGAAAGCCCGCCAGGTATTCGAACTTCCAA
CCCATGGCCACGGCGGCCTGCGACCCGGCGTCGACCTCGACGACAAGGATGCCCTCGCCGAACTGCTGGGCGACAATGCT
GCTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References