252948

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1345774..1346399 Replicon chromosome
Accession NZ_CP101921
Organism Escherichia coli strain QA-1986 83

Toxin (Protein)


Gene name vapC Uniprot ID A0A2J1DF47
Locus tag NP438_RS06555 Protein ID WP_000911331.1
Coordinates 1346001..1346399 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NP438_RS06550 Protein ID WP_000450524.1
Coordinates 1345774..1346001 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP438_RS06525 (1341577) 1341577..1342047 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NP438_RS06530 (1342047) 1342047..1342619 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NP438_RS06535 (1342765) 1342765..1343643 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NP438_RS06540 (1343660) 1343660..1344694 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NP438_RS06545 (1344907) 1344907..1345620 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NP438_RS06550 (1345774) 1345774..1346001 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NP438_RS06555 (1346001) 1346001..1346399 + 399 WP_000911331.1 type II toxin-antitoxin system VapC family toxin Toxin
NP438_RS06560 (1346546) 1346546..1347409 + 864 WP_001267507.1 neutral zinc metallopeptidase -
NP438_RS06565 (1347424) 1347424..1349439 + 2016 WP_001543081.1 tRNA cytosine(34) acetyltransferase TmcA -
NP438_RS06570 (1349513) 1349513..1350211 + 699 WP_000679812.1 esterase -
NP438_RS06575 (1350321) 1350321..1350521 - 201 WP_089631931.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14862.19 Da        Isoelectric Point: 9.2216

>T252948 WP_000911331.1 NZ_CP101921:1346001-1346399 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLVELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT252948 WP_000450524.1 NZ_CP101921:1345774-1346001 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J1DF47

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References