Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 861679..862333 Replicon chromosome
Accession NZ_CP101921
Organism Escherichia coli strain QA-1986 83

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag NP438_RS04200 Protein ID WP_000244772.1
Coordinates 861926..862333 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NP438_RS04195 Protein ID WP_000354046.1
Coordinates 861679..861945 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP438_RS04170 (856848) 856848..857591 + 744 WP_000951964.1 SDR family oxidoreductase -
NP438_RS04175 (857648) 857648..859081 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
NP438_RS04180 (859126) 859126..859437 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
NP438_RS04185 (859601) 859601..860260 + 660 WP_000250274.1 hemolysin III family protein -
NP438_RS04190 (860456) 860456..861436 - 981 WP_000886095.1 tRNA-modifying protein YgfZ -
NP438_RS04195 (861679) 861679..861945 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NP438_RS04200 (861926) 861926..862333 + 408 WP_000244772.1 protein YgfX Toxin
NP438_RS04205 (862373) 862373..862894 - 522 WP_001055874.1 flavodoxin FldB -
NP438_RS04210 (863006) 863006..863902 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NP438_RS04215 (863927) 863927..864637 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NP438_RS04220 (864643) 864643..866376 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T252946 WP_000244772.1 NZ_CP101921:861926-862333 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT252946 WP_000354046.1 NZ_CP101921:861679-861945 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References