Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 274366..274997 Replicon chromosome
Accession NZ_CP101921
Organism Escherichia coli strain QA-1986 83

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag NP438_RS01235 Protein ID WP_001259388.1
Coordinates 274366..274641 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NP438_RS01240 Protein ID WP_000593555.1
Coordinates 274638..274997 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP438_RS01220 (269370) 269370..270437 + 1068 WP_000361485.1 HlyD family secretion protein -
NP438_RS01225 (270434) 270434..273169 + 2736 WP_000149125.1 ribosome-associated ATPase/putative transporter RbbA -
NP438_RS01230 (273169) 273169..274293 + 1125 WP_001314210.1 ABC transporter permease -
NP438_RS01235 (274366) 274366..274641 + 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
NP438_RS01240 (274638) 274638..274997 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NP438_RS01245 (275117) 275117..275518 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NP438_RS01250 (275524) 275524..276330 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
NP438_RS01255 (276327) 276327..277091 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
NP438_RS01260 (277091) 277091..277924 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
NP438_RS01265 (277921) 277921..278865 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T252944 WP_001259388.1 NZ_CP101921:274366-274641 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT252944 WP_000593555.1 NZ_CP101921:274638-274997 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References