Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4502678..4503273 Replicon chromosome
Accession NZ_CP101920
Organism Escherichia coli strain QA-1986 630

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NP447_RS22045 Protein ID WP_000239579.1
Coordinates 4502678..4503028 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NP447_RS22050 Protein ID WP_001223208.1
Coordinates 4503022..4503273 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP447_RS22025 (4498124) 4498124..4499146 - 1023 WP_001296689.1 ABC transporter permease -
NP447_RS22030 (4499160) 4499160..4500662 - 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
NP447_RS22035 (4500802) 4500802..4501758 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NP447_RS22040 (4502068) 4502068..4502598 + 531 WP_000055075.1 inorganic diphosphatase -
NP447_RS22045 (4502678) 4502678..4503028 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NP447_RS22050 (4503022) 4503022..4503273 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NP447_RS22055 (4503485) 4503485..4503826 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NP447_RS22060 (4503829) 4503829..4507608 - 3780 WP_000060896.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T252941 WP_000239579.1 NZ_CP101920:c4503028-4502678 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT252941 WP_001223208.1 NZ_CP101920:c4503273-4503022 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References