Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3708066..3708684 Replicon chromosome
Accession NZ_CP101920
Organism Escherichia coli strain QA-1986 630

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NP447_RS18110 Protein ID WP_001291435.1
Coordinates 3708466..3708684 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E9TLB8
Locus tag NP447_RS18105 Protein ID WP_000344794.1
Coordinates 3708066..3708440 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP447_RS18095 (3703155) 3703155..3704348 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NP447_RS18100 (3704371) 3704371..3707520 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NP447_RS18105 (3708066) 3708066..3708440 + 375 WP_000344794.1 Hha toxicity modulator TomB Antitoxin
NP447_RS18110 (3708466) 3708466..3708684 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NP447_RS18115 (3708855) 3708855..3709406 + 552 WP_000102564.1 maltose O-acetyltransferase -
NP447_RS18120 (3709522) 3709522..3709992 + 471 WP_000136192.1 YlaC family protein -
NP447_RS18125 (3710156) 3710156..3711706 + 1551 WP_114747478.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NP447_RS18130 (3711748) 3711748..3712101 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NP447_RS18140 (3712480) 3712480..3712791 + 312 WP_000409911.1 MGMT family protein -
NP447_RS18145 (3712822) 3712822..3713394 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T252940 WP_001291435.1 NZ_CP101920:3708466-3708684 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14527.36 Da        Isoelectric Point: 4.9284

>AT252940 WP_000344794.1 NZ_CP101920:3708066-3708440 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGRVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References