Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1950637..1951326 Replicon chromosome
Accession NC_015576
Organism Mycobacterium sp. JDM601

Toxin (Protein)


Gene name vapC Uniprot ID F5Z1X3
Locus tag JDM601_RS09100 Protein ID WP_013828735.1
Coordinates 1950895..1951326 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F5Z1X2
Locus tag JDM601_RS09095 Protein ID WP_013828734.1
Coordinates 1950637..1950888 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JDM601_RS09060 1946140..1947648 + 1509 WP_013828727.1 proteasome accessory factor PafA2 -
JDM601_RS09065 1947703..1948092 - 390 WP_013828728.1 PIN domain-containing protein -
JDM601_RS09070 1948089..1948343 - 255 WP_013828729.1 hypothetical protein -
JDM601_RS09075 1948531..1948725 + 195 WP_013828730.1 ubiquitin-like protein Pup -
JDM601_RS09080 1948722..1949606 + 885 WP_041317760.1 proteasome subunit beta -
JDM601_RS09085 1949603..1950349 + 747 WP_013828732.1 proteasome subunit alpha -
JDM601_RS09090 1950358..1950594 - 237 WP_013828733.1 DUF167 domain-containing protein -
JDM601_RS09095 1950637..1950888 + 252 WP_013828734.1 hypothetical protein Antitoxin
JDM601_RS09100 1950895..1951326 + 432 WP_013828735.1 type II toxin-antitoxin system VapC family toxin Toxin
JDM601_RS09105 1951413..1952615 - 1203 WP_013828736.1 lipid-transfer protein -
JDM601_RS09110 1952612..1953055 - 444 WP_041319776.1 OB-fold domain-containing protein -
JDM601_RS09115 1953152..1955890 + 2739 WP_013828738.1 DNA polymerase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15414.46 Da        Isoelectric Point: 5.8935

>T25294 WP_013828735.1 NC_015576:1950895-1951326 [Mycolicibacter sinensis]
MKIVDANVLLYAVNTAAEHHDASLRWLDRALSGADTVGFAWVPLLAFVRLSTKEGLFPHPLRPEDAVDRVAEWTAASSAV
VVNPTPRHADILTGLLARVGAGGNLVNDAHLAALAIEHRGGIVSYDADFGRFGIRWDRPDDLA

Download         Length: 432 bp

>T25294 NC_015576:1950895-1951326 [Mycolicibacter sinensis]
ATGAAGATCGTCGACGCCAATGTGTTGCTCTATGCGGTGAACACTGCCGCAGAGCACCATGACGCCTCGCTGCGCTGGCT
CGACCGTGCGCTGTCCGGAGCGGACACGGTTGGCTTCGCCTGGGTTCCGCTACTGGCGTTCGTCCGGCTCTCCACCAAGG
AGGGTTTGTTTCCCCATCCGCTGCGGCCAGAGGACGCGGTGGACCGGGTGGCCGAGTGGACCGCGGCATCTAGTGCGGTA
GTCGTCAATCCCACGCCTCGACATGCCGACATCCTGACCGGGCTGCTCGCCCGCGTCGGCGCCGGGGGAAACCTGGTGAA
CGACGCGCACCTGGCGGCGCTCGCCATCGAGCACCGCGGCGGAATCGTTTCCTACGACGCGGATTTCGGCCGATTCGGGA
TCCGTTGGGATCGGCCCGACGACCTGGCGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9422.59 Da        Isoelectric Point: 6.3412

>AT25294 WP_013828734.1 NC_015576:1950637-1950888 [Mycolicibacter sinensis]
MRTTVTLDDDVEQLIRRRMAERQLSFKQALNEAIRDGSAGRATPQFQTRTADLGVPSVNLDRALQLAADLEDEELIRRQR
RGA

Download         Length: 252 bp

>AT25294 NC_015576:1950637-1950888 [Mycolicibacter sinensis]
ATGCGCACCACCGTGACATTGGATGATGACGTCGAGCAGTTGATTCGTCGCCGGATGGCAGAACGTCAGCTGTCGTTCAA
GCAGGCGCTCAACGAGGCGATCCGCGACGGATCGGCCGGCCGCGCAACACCGCAATTCCAGACCCGGACCGCTGATCTCG
GGGTCCCGTCGGTCAATCTGGACAGGGCACTGCAGCTTGCTGCGGATCTGGAGGACGAAGAGCTGATCCGCCGGCAACGC
CGCGGTGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I9Y887

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7JGW9

References