Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2587113..2587751 Replicon chromosome
Accession NZ_CP101920
Organism Escherichia coli strain QA-1986 630

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NP447_RS12280 Protein ID WP_000813794.1
Coordinates 2587575..2587751 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NP447_RS12275 Protein ID WP_001270286.1
Coordinates 2587113..2587529 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP447_RS12255 (2582265) 2582265..2583206 - 942 WP_001251315.1 ABC transporter permease -
NP447_RS12260 (2583207) 2583207..2584220 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NP447_RS12265 (2584238) 2584238..2585383 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NP447_RS12270 (2585628) 2585628..2587034 - 1407 WP_000760663.1 PLP-dependent aminotransferase family protein -
NP447_RS12275 (2587113) 2587113..2587529 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NP447_RS12280 (2587575) 2587575..2587751 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NP447_RS12285 (2587973) 2587973..2588203 + 231 WP_000494244.1 YncJ family protein -
NP447_RS12290 (2588295) 2588295..2590256 - 1962 WP_001442195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NP447_RS12295 (2590329) 2590329..2590865 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NP447_RS12300 (2590957) 2590957..2592132 + 1176 WP_001583501.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2592172..2593320 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T252938 WP_000813794.1 NZ_CP101920:c2587751-2587575 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT252938 WP_001270286.1 NZ_CP101920:c2587529-2587113 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References