Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1473786..1474411 Replicon chromosome
Accession NZ_CP101920
Organism Escherichia coli strain QA-1986 630

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NP447_RS07025 Protein ID WP_000911330.1
Coordinates 1474013..1474411 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NP447_RS07020 Protein ID WP_000450524.1
Coordinates 1473786..1474013 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP447_RS06995 (1469589) 1469589..1470059 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NP447_RS07000 (1470059) 1470059..1470631 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NP447_RS07005 (1470777) 1470777..1471655 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NP447_RS07010 (1471672) 1471672..1472706 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NP447_RS07015 (1472919) 1472919..1473632 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NP447_RS07020 (1473786) 1473786..1474013 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NP447_RS07025 (1474013) 1474013..1474411 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NP447_RS07030 (1474558) 1474558..1475421 + 864 WP_001267498.1 neutral zinc metallopeptidase -
NP447_RS07035 (1475436) 1475436..1477451 + 2016 WP_001402395.1 tRNA cytosine(34) acetyltransferase TmcA -
NP447_RS07040 (1477525) 1477525..1478223 + 699 WP_000679812.1 esterase -
NP447_RS07045 (1478333) 1478333..1478533 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T252931 WP_000911330.1 NZ_CP101920:1474013-1474411 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT252931 WP_000450524.1 NZ_CP101920:1473786-1474013 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References