Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4100761..4101356 Replicon chromosome
Accession NZ_CP101915
Organism Escherichia coli strain Evo1

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NP443_RS19935 Protein ID WP_000239579.1
Coordinates 4100761..4101111 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NP443_RS19940 Protein ID WP_001223208.1
Coordinates 4101105..4101356 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP443_RS19915 (4096207) 4096207..4097229 - 1023 WP_001295197.1 ABC transporter permease -
NP443_RS19920 (4097243) 4097243..4098745 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
NP443_RS19925 (4098885) 4098885..4099841 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NP443_RS19930 (4100151) 4100151..4100681 + 531 WP_000055072.1 inorganic diphosphatase -
NP443_RS19935 (4100761) 4100761..4101111 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NP443_RS19940 (4101105) 4101105..4101356 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NP443_RS19945 (4101568) 4101568..4101909 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NP443_RS19950 (4101912) 4101912..4105691 - 3780 WP_000060978.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T252921 WP_000239579.1 NZ_CP101915:c4101111-4100761 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT252921 WP_001223208.1 NZ_CP101915:c4101356-4101105 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References