Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3473629..3474247 Replicon chromosome
Accession NZ_CP101915
Organism Escherichia coli strain Evo1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NP443_RS16920 Protein ID WP_001291435.1
Coordinates 3474029..3474247 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NP443_RS16915 Protein ID WP_000344800.1
Coordinates 3473629..3474003 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP443_RS16905 (3468718) 3468718..3469911 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NP443_RS16910 (3469934) 3469934..3473083 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NP443_RS16915 (3473629) 3473629..3474003 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NP443_RS16920 (3474029) 3474029..3474247 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NP443_RS16925 (3474419) 3474419..3474970 + 552 WP_000102564.1 maltose O-acetyltransferase -
NP443_RS16930 (3475086) 3475086..3475556 + 471 WP_000136192.1 YlaC family protein -
NP443_RS16935 (3475720) 3475720..3477270 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NP443_RS16940 (3477312) 3477312..3477665 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NP443_RS16950 (3478044) 3478044..3478355 + 312 WP_000409911.1 MGMT family protein -
NP443_RS16955 (3478386) 3478386..3478958 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T252917 WP_001291435.1 NZ_CP101915:3474029-3474247 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT252917 WP_000344800.1 NZ_CP101915:3473629-3474003 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References