Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 850381..851035 Replicon chromosome
Accession NZ_CP101915
Organism Escherichia coli strain Evo1

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NP443_RS04155 Protein ID WP_000244777.1
Coordinates 850628..851035 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NP443_RS04150 Protein ID WP_000354046.1
Coordinates 850381..850647 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP443_RS04125 (845550) 845550..846293 + 744 WP_000951964.1 SDR family oxidoreductase -
NP443_RS04130 (846350) 846350..847783 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
NP443_RS04135 (847828) 847828..848139 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
NP443_RS04140 (848303) 848303..848962 + 660 WP_000250274.1 hemolysin III family protein -
NP443_RS04145 (849158) 849158..850138 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NP443_RS04150 (850381) 850381..850647 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NP443_RS04155 (850628) 850628..851035 + 408 WP_000244777.1 protein YgfX Toxin
NP443_RS04160 (851075) 851075..851596 - 522 WP_001055874.1 flavodoxin FldB -
NP443_RS04165 (851708) 851708..852604 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NP443_RS04170 (852629) 852629..853339 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NP443_RS04175 (853345) 853345..855078 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T252907 WP_000244777.1 NZ_CP101915:850628-851035 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT252907 WP_000354046.1 NZ_CP101915:850381-850647 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References