Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 259626..260257 Replicon chromosome
Accession NZ_CP101915
Organism Escherichia coli strain Evo1

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag NP443_RS01180 Protein ID WP_001259385.1
Coordinates 259626..259901 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NP443_RS01185 Protein ID WP_000593555.1
Coordinates 259898..260257 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP443_RS01165 (254630) 254630..255697 + 1068 WP_000361491.1 HlyD family efflux transporter periplasmic adaptor subunit -
NP443_RS01170 (255694) 255694..258429 + 2736 WP_032294472.1 ribosome-associated ATPase/putative transporter RbbA -
NP443_RS01175 (258429) 258429..259553 + 1125 WP_001488398.1 ABC transporter permease -
NP443_RS01180 (259626) 259626..259901 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
NP443_RS01185 (259898) 259898..260257 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NP443_RS01190 (260377) 260377..260778 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NP443_RS01195 (260784) 260784..261590 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
NP443_RS01200 (261587) 261587..262351 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
NP443_RS01205 (262351) 262351..263184 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
NP443_RS01210 (263181) 263181..264125 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T252904 WP_001259385.1 NZ_CP101915:259626-259901 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT252904 WP_000593555.1 NZ_CP101915:259898-260257 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References