Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1140240..1140895 Replicon chromosome
Accession NZ_CP101913
Organism Oceanobacillus oncorhynchi strain QA-1986 526

Toxin (Protein)


Gene name mazF Uniprot ID A0A0A1MUC5
Locus tag NP440_RS05670 Protein ID WP_042532419.1
Coordinates 1140533..1140895 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag NP440_RS05665 Protein ID WP_042532417.1
Coordinates 1140240..1140527 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP440_RS05645 (NP440_05645) 1135798..1136583 - 786 WP_256705800.1 rhomboid family intramembrane serine protease -
NP440_RS05650 (NP440_05650) 1136715..1137071 + 357 WP_193064389.1 holo-ACP synthase -
NP440_RS05655 (NP440_05655) 1137155..1138672 + 1518 WP_193064388.1 NAD(P)H-hydrate dehydratase -
NP440_RS05660 (NP440_05660) 1138736..1139773 + 1038 WP_042532414.1 outer membrane lipoprotein carrier protein LolA -
NP440_RS05665 (NP440_05665) 1140240..1140527 + 288 WP_042532417.1 hypothetical protein Antitoxin
NP440_RS05670 (NP440_05670) 1140533..1140895 + 363 WP_042532419.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NP440_RS05675 (NP440_05675) 1141394..1142107 + 714 WP_042532423.1 HAD family hydrolase -
NP440_RS05680 (NP440_05680) 1142720..1143130 + 411 WP_256705801.1 NADPH-dependent FMN reductase -
NP440_RS05685 (NP440_05685) 1143545..1144414 + 870 WP_042532426.1 RsbT co-antagonist protein RsbRA -
NP440_RS05690 (NP440_05690) 1144420..1144776 + 357 WP_042532428.1 STAS domain-containing protein -
NP440_RS05695 (NP440_05695) 1144780..1145181 + 402 WP_042532430.1 anti-sigma regulatory factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13493.58 Da        Isoelectric Point: 8.4725

>T252902 WP_042532419.1 NZ_CP101913:1140533-1140895 [Oceanobacillus oncorhynchi]
VIVQRGEVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFDRNSVILLEQI
RTLDKQRLTDKITKLDKEMMEKINQSLEISLGLRDVYSNN

Download         Length: 363 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11018.43 Da        Isoelectric Point: 4.3531

>AT252902 WP_042532417.1 NZ_CP101913:1140240-1140527 [Oceanobacillus oncorhynchi]
MAENKEEILVKIPKNLLSEVDGLMKYENSSDLSDFICEATQIYLNHKKEEHLQRFHETMQRGYEEMARINLTIASEAFQA
EEEAEITLERSVIGV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1MUC5

Antitoxin

Source ID Structure

References