Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5537877..5538463 Replicon chromosome
Accession NZ_CP101912
Organism Pseudomonas aeruginosa strain ATCC 27853

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag NP446_RS26200 Protein ID WP_003120987.1
Coordinates 5538164..5538463 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag NP446_RS26195 Protein ID WP_003448662.1
Coordinates 5537877..5538167 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP446_RS26175 (NP446_26175) 5533028..5533237 + 210 WP_003105733.1 cold-shock protein -
NP446_RS26180 (NP446_26180) 5533459..5535348 + 1890 WP_016851610.1 hypothetical protein -
NP446_RS26185 (NP446_26185) 5535345..5537321 + 1977 WP_016851611.1 DEAD/DEAH box helicase -
NP446_RS26190 (NP446_26190) 5537462..5537806 + 345 WP_016851612.1 hypothetical protein -
NP446_RS26195 (NP446_26195) 5537877..5538167 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
NP446_RS26200 (NP446_26200) 5538164..5538463 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP446_RS26205 (NP446_26205) 5538665..5539789 + 1125 WP_012076859.1 TcpQ domain-containing protein -
NP446_RS26210 (NP446_26210) 5539789..5541498 + 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
NP446_RS26215 (NP446_26215) 5541502..5542827 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
NP446_RS26220 (NP446_26220) 5542817..5543350 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5510898..5613734 102836


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T252900 WP_003120987.1 NZ_CP101912:c5538463-5538164 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT252900 WP_003448662.1 NZ_CP101912:c5538167-5537877 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References