Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5140889..5141497 Replicon chromosome
Accession NZ_CP101912
Organism Pseudomonas aeruginosa strain ATCC 27853

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag NP446_RS24350 Protein ID WP_003123043.1
Coordinates 5140889..5141236 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag NP446_RS24355 Protein ID WP_003114155.1
Coordinates 5141246..5141497 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP446_RS24325 (NP446_24325) 5137165..5138397 + 1233 WP_016852057.1 phosphoadenosine phosphosulfate reductase family protein -
NP446_RS24330 (NP446_24330) 5138408..5138584 + 177 WP_016852058.1 hypothetical protein -
NP446_RS24335 (NP446_24335) 5138581..5138949 + 369 WP_016852059.1 ASCH domain-containing protein -
NP446_RS24340 (NP446_24340) 5139142..5139345 + 204 WP_003098423.1 AlpA family phage regulatory protein -
NP446_RS24345 (NP446_24345) 5139352..5140554 - 1203 WP_016852061.1 integrase family protein -
NP446_RS24350 (NP446_24350) 5140889..5141236 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP446_RS24355 (NP446_24355) 5141246..5141497 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NP446_RS24360 (NP446_24360) 5141711..5142694 - 984 WP_016852062.1 tyrosine-type recombinase/integrase -
NP446_RS24365 (NP446_24365) 5142694..5143986 - 1293 WP_003115206.1 hypothetical protein -
NP446_RS24370 (NP446_24370) 5144245..5145506 - 1262 Protein_4824 hypothetical protein -
NP446_RS24375 (NP446_24375) 5145508..5145858 - 351 WP_003159569.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5017357..5152816 135459


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T252899 WP_003123043.1 NZ_CP101912:c5141236-5140889 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT252899 WP_003114155.1 NZ_CP101912:c5141497-5141246 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References