Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4657211..4658469 Replicon chromosome
Accession NZ_CP101912
Organism Pseudomonas aeruginosa strain ATCC 27853

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag NP446_RS21955 Protein ID WP_003112528.1
Coordinates 4657211..4657966 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag NP446_RS21960 Protein ID WP_003086329.1
Coordinates 4658101..4658469 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP446_RS21945 (NP446_21945) 4652384..4654927 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
NP446_RS21950 (NP446_21950) 4655082..4656443 - 1362 WP_073647918.1 DNA recombination protein RmuC -
NP446_RS21955 (NP446_21955) 4657211..4657966 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
NP446_RS21960 (NP446_21960) 4658101..4658469 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
NP446_RS21965 (NP446_21965) 4658542..4659828 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
NP446_RS21970 (NP446_21970) 4659884..4661473 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
NP446_RS21975 (NP446_21975) 4661552..4662028 + 477 WP_003112531.1 hypothetical protein -
NP446_RS21980 (NP446_21980) 4662031..4662306 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T252898 WP_003112528.1 NZ_CP101912:c4657966-4657211 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT252898 WP_003086329.1 NZ_CP101912:c4658469-4658101 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References