252896

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2691366..2692408 Replicon chromosome
Accession NZ_CP101912
Organism Pseudomonas aeruginosa strain ATCC 27853

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag NP446_RS13000 Protein ID WP_003153636.1
Coordinates 2691833..2692408 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag NP446_RS12995 Protein ID WP_003050245.1
Coordinates 2691366..2691836 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP446_RS12960 (NP446_12960) 2686758..2688176 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
NP446_RS12965 (NP446_12965) 2688166..2689077 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
NP446_RS12970 (NP446_12970) 2689074..2689766 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
NP446_RS12975 (NP446_12975) 2689763..2690161 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
NP446_RS12980 (NP446_12980) 2690173..2690532 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
NP446_RS12985 (NP446_12985) 2690549..2690782 - 234 WP_003090170.1 TIGR03758 family integrating conjugative element protein -
NP446_RS12990 (NP446_12990) 2690779..2691162 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
NP446_RS12995 (NP446_12995) 2691366..2691836 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
NP446_RS13000 (NP446_13000) 2691833..2692408 + 576 WP_003153636.1 PIN domain-containing protein Toxin
NP446_RS13005 (NP446_13005) 2692426..2693340 + 915 WP_016852809.1 AAA family ATPase -
NP446_RS13010 (NP446_13010) 2693337..2693807 + 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
NP446_RS13015 (NP446_13015) 2693804..2694304 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
NP446_RS13020 (NP446_13020) 2694304..2695206 + 903 WP_003090158.1 CBASS oligonucleotide cyclase -
NP446_RS13025 (NP446_13025) 2695245..2695970 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2616802..2738506 121704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T252896 WP_003153636.1 NZ_CP101912:2691833-2692408 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT252896 WP_003050245.1 NZ_CP101912:2691366-2691836 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References