Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 148725..149230 Replicon chromosome
Accession NZ_CP101912
Organism Pseudomonas aeruginosa strain ATCC 27853

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag NP446_RS00670 Protein ID WP_003121619.1
Coordinates 148725..149006 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag NP446_RS00675 Protein ID WP_003112628.1
Coordinates 149003..149230 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP446_RS00645 (NP446_00645) 143976..145325 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
NP446_RS00650 (NP446_00650) 145374..146060 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
NP446_RS00655 (NP446_00655) 146161..146895 + 735 WP_003117208.1 GntR family transcriptional regulator -
NP446_RS00660 (NP446_00660) 147075..147485 + 411 WP_003101225.1 aegerolysin family protein -
NP446_RS00665 (NP446_00665) 147517..148425 - 909 WP_016561475.1 LysR family transcriptional regulator -
NP446_RS00670 (NP446_00670) 148725..149006 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
NP446_RS00675 (NP446_00675) 149003..149230 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
NP446_RS00680 (NP446_00680) 149406..150026 - 621 WP_003101226.1 hypothetical protein -
NP446_RS00685 (NP446_00685) 150127..150627 + 501 WP_003112629.1 LEA type 2 family protein -
NP446_RS00690 (NP446_00690) 150700..151041 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
NP446_RS00695 (NP446_00695) 151123..152550 - 1428 WP_003083784.1 GABA permease -
NP446_RS00700 (NP446_00700) 152719..154212 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T252894 WP_003121619.1 NZ_CP101912:c149006-148725 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT252894 WP_003112628.1 NZ_CP101912:c149230-149003 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References