Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4439317..4440575 Replicon chromosome
Accession NZ_CP101911
Organism Pseudomonas aeruginosa strain NWRC-1223

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag NP444_RS20535 Protein ID WP_003163133.1
Coordinates 4439317..4440072 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag NP444_RS20540 Protein ID WP_003086329.1
Coordinates 4440207..4440575 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP444_RS20525 (NP444_20525) 4434489..4437032 + 2544 WP_003123188.1 acyl-homoserine-lactone acylase QuiP -
NP444_RS20530 (NP444_20530) 4437187..4438548 - 1362 WP_003081943.1 DNA recombination protein RmuC -
NP444_RS20535 (NP444_20535) 4439317..4440072 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
NP444_RS20540 (NP444_20540) 4440207..4440575 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
NP444_RS20545 (NP444_20545) 4440648..4441934 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
NP444_RS20550 (NP444_20550) 4441990..4443579 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
NP444_RS20555 (NP444_20555) 4443658..4444134 + 477 WP_003112531.1 hypothetical protein -
NP444_RS20560 (NP444_20560) 4444137..4444412 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T252892 WP_003163133.1 NZ_CP101911:c4440072-4439317 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT252892 WP_003086329.1 NZ_CP101911:c4440575-4440207 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References