Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3524838..3526059 Replicon chromosome
Accession NZ_CP101911
Organism Pseudomonas aeruginosa strain NWRC-1223

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NP444_RS16220 Protein ID WP_003114949.1
Coordinates 3525481..3526059 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NP444_RS16215 Protein ID WP_003088112.1
Coordinates 3524838..3525392 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP444_RS16190 (NP444_16190) 3520406..3520957 + 552 WP_004343115.1 XRE family transcriptional regulator -
NP444_RS16195 (NP444_16195) 3520954..3521352 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
NP444_RS16200 (NP444_16200) 3521365..3521688 - 324 WP_003102734.1 multidrug efflux SMR transporter -
NP444_RS16205 (NP444_16205) 3522019..3522480 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
NP444_RS16210 (NP444_16210) 3522485..3524680 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
NP444_RS16215 (NP444_16215) 3524838..3525392 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
NP444_RS16220 (NP444_16220) 3525481..3526059 + 579 WP_003114949.1 HD domain-containing protein Toxin
NP444_RS16225 (NP444_16225) 3526167..3527354 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
NP444_RS16230 (NP444_16230) 3527344..3529515 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
NP444_RS16235 (NP444_16235) 3529505..3530782 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T252891 WP_003114949.1 NZ_CP101911:3525481-3526059 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT252891 WP_003088112.1 NZ_CP101911:3524838-3525392 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References