Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1850811..1852319 Replicon chromosome
Accession NZ_CP101911
Organism Pseudomonas aeruginosa strain NWRC-1223

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag NP444_RS08560 Protein ID WP_073666805.1
Coordinates 1850811..1851398 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag NP444_RS08565 Protein ID WP_003091607.1
Coordinates 1851465..1852319 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP444_RS08555 (NP444_08555) 1847066..1850545 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
NP444_RS08560 (NP444_08560) 1850811..1851398 + 588 WP_073666805.1 GNAT family protein Toxin
NP444_RS08565 (NP444_08565) 1851465..1852319 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
NP444_RS08570 (NP444_08570) 1852416..1854581 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
NP444_RS08575 (NP444_08575) 1854756..1856630 + 1875 WP_003117607.1 MFS transporter -
NP444_RS08580 (NP444_08580) 1856691..1856900 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21887.20 Da        Isoelectric Point: 9.8676

>T252890 WP_073666805.1 NZ_CP101911:1850811-1851398 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLADQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT252890 WP_003091607.1 NZ_CP101911:1851465-1852319 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References