Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 290287..290918 Replicon chromosome
Accession NC_015576
Organism Mycobacterium sp. JDM601

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JDM601_RS01355 Protein ID WP_013827215.1
Coordinates 290502..290918 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JDM601_RS01350 Protein ID WP_013827214.1
Coordinates 290287..290505 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JDM601_RS01325 285782..287569 - 1788 WP_013827210.1 selenocysteine-specific translation elongation factor -
JDM601_RS01330 287583..288896 - 1314 WP_013827211.1 L-seryl-tRNA(Sec) selenium transferase -
JDM601_RS01340 289044..290021 + 978 WP_013827212.1 selenide, water dikinase SelD -
JDM601_RS01345 290024..290236 + 213 WP_041316765.1 DUF2945 domain-containing protein -
JDM601_RS01350 290287..290505 + 219 WP_013827214.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JDM601_RS01355 290502..290918 + 417 WP_013827215.1 ribonuclease Toxin
JDM601_RS01360 290931..292649 - 1719 WP_013827216.1 urease subunit alpha -
JDM601_RS01365 292646..293038 - 393 WP_013827217.1 urease subunit beta -
JDM601_RS01370 293053..293354 - 302 Protein_276 urease subunit gamma -
JDM601_RS01375 293490..294539 - 1050 WP_041316770.1 polysulfide reductase NrfD -
JDM601_RS01380 294536..295501 - 966 WP_013827220.1 4Fe-4S dicluster domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(4-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15246.29 Da        Isoelectric Point: 6.2220

>T25289 WP_013827215.1 NC_015576:290502-290918 [Mycolicibacter sinensis]
MISFLADSSAIWRLQRQPELTQAWNSALLSGAIGSCDPQRAEFRRSARNANEFEQMSQMFRDIYPDVPVPKSVWRWIDTA
QHRLAAAGAVRALSVVDLLVCATGAAKGLTILHDDGDYELAARHLPDVAARRVVDVDA

Download         Length: 417 bp

>T25289 NC_015576:290502-290918 [Mycolicibacter sinensis]
TTGATTTCTTTCCTGGCTGACTCCTCGGCCATCTGGCGGTTGCAACGACAGCCGGAACTGACCCAAGCGTGGAACTCCGC
TCTGCTCAGTGGGGCGATCGGATCGTGCGATCCGCAGCGGGCGGAGTTTCGTCGTTCGGCCCGCAATGCCAACGAGTTCG
AACAGATGAGCCAGATGTTTCGTGACATCTATCCCGATGTTCCCGTGCCGAAATCCGTGTGGCGGTGGATAGACACCGCC
CAGCACCGATTGGCGGCAGCGGGCGCGGTGCGTGCACTGTCGGTCGTCGACCTGCTGGTCTGCGCTACGGGTGCGGCCAA
GGGGTTGACAATTCTTCATGACGACGGCGATTACGAACTGGCCGCGCGTCACCTGCCTGATGTCGCGGCCCGCCGTGTTG
TCGATGTCGACGCGTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8379.45 Da        Isoelectric Point: 4.8232

>AT25289 WP_013827214.1 NC_015576:290287-290505 [Mycolicibacter sinensis]
MAVTQIDLDDEALREVMRIAGVHTKKEAVNLAMRDYVERFRRIEALARSREQAQDWDYDGWLVARADEKVTG

Download         Length: 219 bp

>AT25289 NC_015576:290287-290505 [Mycolicibacter sinensis]
ATGGCGGTAACCCAGATCGACCTTGACGACGAAGCGCTGCGCGAGGTCATGCGGATCGCCGGGGTGCACACCAAGAAAGA
GGCGGTCAACCTCGCGATGCGCGATTATGTCGAACGGTTCAGGCGCATCGAGGCGCTCGCCCGATCCCGCGAACAGGCTC
AGGACTGGGATTACGACGGGTGGCTCGTGGCGCGCGCCGACGAGAAGGTCACCGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References