Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 3834005..3834888 Replicon chromosome
Accession NZ_CP101910
Organism Pseudomonas putida strain ATCC 12633

Toxin (Protein)


Gene name - Uniprot ID R9VG37
Locus tag NP430_RS17125 Protein ID WP_016487683.1
Coordinates 3834005..3834442 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R9VFG2
Locus tag NP430_RS17130 Protein ID WP_016487684.1
Coordinates 3834439..3834888 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP430_RS17110 (NP430_17110) 3830355..3831584 - 1230 WP_016499069.1 acyl-CoA dehydrogenase -
NP430_RS17115 (NP430_17115) 3831724..3832650 + 927 WP_016499068.1 LysR family transcriptional regulator -
NP430_RS17120 (NP430_17120) 3832843..3833997 + 1155 WP_016499067.1 aminotransferase class V-fold PLP-dependent enzyme -
NP430_RS17125 (NP430_17125) 3834005..3834442 - 438 WP_016487683.1 RES family NAD+ phosphorylase Toxin
NP430_RS17130 (NP430_17130) 3834439..3834888 - 450 WP_016487684.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
NP430_RS17135 (NP430_17135) 3834995..3835771 - 777 WP_016499066.1 SDR family oxidoreductase -
NP430_RS17140 (NP430_17140) 3835942..3836862 - 921 WP_016499065.1 LysR family transcriptional regulator -
NP430_RS17145 (NP430_17145) 3837155..3837877 - 723 WP_016499064.1 hypothetical protein -
NP430_RS17150 (NP430_17150) 3837957..3838256 - 300 WP_041167675.1 DUF3077 domain-containing protein -
NP430_RS17155 (NP430_17155) 3838455..3839078 + 624 WP_016499062.1 glutathione S-transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-138)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(33-91)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 16005.35 Da        Isoelectric Point: 6.2187

>T252883 WP_016487683.1 NZ_CP101910:c3834442-3834005 [Pseudomonas putida]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPSGAMLEVLVHLEIDPEDFPTTMRLIRIELPDTVSQAQLPALQ
PGWSAQPELTRALGNRFLDDCSALLLPVPSAIMPSTINYLFNPRHAQAQRAKIQVEDFTPDSRLF

Download         Length: 438 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 17096.64 Da        Isoelectric Point: 6.1089

>AT252883 WP_016487684.1 NZ_CP101910:c3834888-3834439 [Pseudomonas putida]
MLAEVLRDNGYHEYRARLQALLEIPELASDFEIHTRITHGFAATWLVKLTERGVFTPVERDQIIPLRTLKTRIERDQPLT
VEESDRLFRSAHITAMAEAVFGEADKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGFGL

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R9VG37

Antitoxin

Source ID Structure
AlphaFold DB R9VFG2

References