Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2249740..2250256 Replicon chromosome
Accession NZ_CP101910
Organism Pseudomonas putida strain ATCC 12633

Toxin (Protein)


Gene name relE Uniprot ID A0A1X0ZEG5
Locus tag NP430_RS10140 Protein ID WP_016500419.1
Coordinates 2249975..2250256 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1X0ZEN3
Locus tag NP430_RS10135 Protein ID WP_016500420.1
Coordinates 2249740..2249985 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP430_RS10110 (NP430_10110) 2245249..2246172 - 924 WP_016486010.1 LysR family transcriptional regulator -
NP430_RS10115 (NP430_10115) 2246277..2246930 + 654 WP_016500424.1 oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB -
NP430_RS10120 (NP430_10120) 2246983..2247918 - 936 WP_016500423.1 cyclase family protein -
NP430_RS10125 (NP430_10125) 2248015..2248557 - 543 WP_016500422.1 WYL domain-containing protein -
NP430_RS10130 (NP430_10130) 2248675..2249472 - 798 WP_059395093.1 SDR family oxidoreductase -
NP430_RS10135 (NP430_10135) 2249740..2249985 + 246 WP_016500420.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NP430_RS10140 (NP430_10140) 2249975..2250256 + 282 WP_016500419.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP430_RS10145 (NP430_10145) 2250276..2250908 - 633 WP_016500418.1 BRCT domain-containing protein -
NP430_RS10150 (NP430_10150) 2250925..2251320 - 396 WP_115283715.1 hypothetical protein -
NP430_RS10155 (NP430_10155) 2251441..2252349 - 909 WP_016500416.1 LysR family transcriptional regulator -
NP430_RS10160 (NP430_10160) 2252641..2253945 + 1305 WP_016500415.1 MFS transporter -
NP430_RS10165 (NP430_10165) 2253977..2255215 + 1239 WP_016500414.1 Zn-dependent hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-76)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10895.82 Da        Isoelectric Point: 10.6492

>T252882 WP_016500419.1 NZ_CP101910:2249975-2250256 [Pseudomonas putida]
MTYKLEFLPSALKEWGKLGHTVREQIKKKLGERLQSPKVQADALRDLPNHYKIKLKACGYRLVYRVEDERIVVVVVSVGK
RERSEVYRAAQKR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8809.23 Da        Isoelectric Point: 4.3611

>AT252882 WP_016500420.1 NZ_CP101910:2249740-2249985 [Pseudomonas putida]
MQNIFADVTVSVSELKKNPSAVMTGAAGMPVAVLNHNRVMGYMVPAELYEAMMERLEDLELSELAKSRLGEKGVPVSLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X0ZEG5

Antitoxin

Source ID Structure
AlphaFold DB A0A1X0ZEN3

References