Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3962115..3962740 Replicon chromosome
Accession NZ_CP101907
Organism Salmonella enterica subsp. enterica strain QA-1986 973

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NP441_RS19495 Protein ID WP_000911337.1
Coordinates 3962342..3962740 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag NP441_RS19490 Protein ID WP_000557545.1
Coordinates 3962115..3962342 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP441_RS19460 (3957178) 3957178..3958276 + 1099 WP_010989230.1 peptide chain release factor 2 -
NP441_RS19465 (3958286) 3958286..3959803 + 1518 WP_000003339.1 lysine--tRNA ligase -
NP441_RS19470 (3959879) 3959879..3960424 - 546 WP_050067887.1 isopentenyl-diphosphate Delta-isomerase -
NP441_RS19475 (3960689) 3960689..3961447 + 759 WP_077947050.1 amidase activator ActS -
NP441_RS19485 (3961693) 3961693..3961906 - 214 Protein_3792 hypothetical protein -
NP441_RS19490 (3962115) 3962115..3962342 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
NP441_RS19495 (3962342) 3962342..3962740 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
NP441_RS19500 (3963541) 3963541..3964077 + 537 WP_058652987.1 STM3031 family outer membrane protein -
NP441_RS19505 (3964124) 3964124..3964756 + 633 WP_000835265.1 YfdX family protein -
NP441_RS19510 (3965475) 3965475..3966059 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3962115..3970531 8416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T252876 WP_000911337.1 NZ_CP101907:3962342-3962740 [Salmonella enterica subsp. enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT252876 WP_000557545.1 NZ_CP101907:3962115-3962342 [Salmonella enterica subsp. enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References