252870

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2534701..2535482 Replicon chromosome
Accession NZ_CP101907
Organism Salmonella enterica subsp. enterica strain QA-1986 973

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag NP441_RS12505 Protein ID WP_000625911.1
Coordinates 2534701..2535192 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag NP441_RS12510 Protein ID WP_001271379.1
Coordinates 2535189..2535482 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP441_RS12480 (2531581) 2531581..2532411 - 831 WP_023221225.1 fimbria/pilus periplasmic chaperone -
NP441_RS12485 (2532613) 2532613..2532825 - 213 WP_001293880.1 PapB/FocB family fimbrial expression transcriptional regulator -
NP441_RS12490 (2533451) 2533451..2533594 + 144 Protein_2439 transposase -
NP441_RS12495 (2533611) 2533611..2533957 + 347 Protein_2440 Rpn family recombination-promoting nuclease/putative transposase -
NP441_RS12500 (2534238) 2534238..2534486 - 249 Protein_2441 IS481 family transposase -
NP441_RS12505 (2534701) 2534701..2535192 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
NP441_RS12510 (2535189) 2535189..2535482 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
NP441_RS12515 (2535800) 2535800..2536022 + 223 Protein_2444 hypothetical protein -
NP441_RS12520 (2536288) 2536288..2537163 + 876 WP_058653569.1 AraC family transcriptional regulator -
NP441_RS12525 (2537160) 2537160..2537447 + 288 WP_001269916.1 transcriptional regulator RtsB -
NP441_RS12530 (2537440) 2537440..2537622 - 183 WP_071591272.1 ATP-binding cassette domain-containing protein -
NP441_RS12535 (2537642) 2537642..2537741 + 100 Protein_2448 hypothetical protein -
NP441_RS12540 (2537849) 2537849..2537983 + 135 Protein_2449 hypothetical protein -
NP441_RS12545 (2538278) 2538278..2539183 - 906 WP_058653032.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2524093..2537447 13354


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T252870 WP_000625911.1 NZ_CP101907:c2535192-2534701 [Salmonella enterica subsp. enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT252870 WP_001271379.1 NZ_CP101907:c2535482-2535189 [Salmonella enterica subsp. enterica]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References