Detailed information of TA system TA025287

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2531097..2531650
• Replicon: chromosome
• Accession: NC_015572
• Organism: Methylomonas methanica MC09

Toxin (Protein)

• Gene name: parE
• Uniprot ID: F9ZVA8
• Locus tag: METME_RS11640
• Protein ID: WP_013818958.1
• Coordinates: 2531360..2531650 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: F9ZVA7
• Locus tag: METME_RS11635
• Protein ID: WP_013818957.1
• Coordinates: 2531097..2531357 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
METME_RS11605	2526255..2526596	-	342	WP_013818952.1	hypothetical protein	-
METME_RS11610	2526593..2527903	-	1311	WP_013818953.1	hypothetical protein	-
METME_RS11615	2527920..2528189	-	270	WP_013818954.1	WXG100 family type VII secretion target	-
METME_RS11620	2528189..2528923	-	735	WP_013818955.1	VWA domain-containing protein	-
METME_RS11625	2529253..2530167	-	915	WP_013818956.1	WYL domain-containing protein	-
METME_RS11635	2531097..2531357	+	261	WP_013818957.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
METME_RS11640	2531360..2531650	+	291	WP_013818958.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
METME_RS11645	2532062..2532958	-	897	WP_148262109.1	hypothetical protein	-
METME_RS11650	2532981..2534210	-	1230	WP_013818960.1	hypothetical protein	-
METME_RS11655	2534207..2534839	-	633	WP_013818961.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2511152..2531650	20498

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-92)

Antitoxin

• Antitoxin ParD (5-74)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11400.03 Da
• Isoelectric Point: 7.4700

>T25287 WP_013818958.1 NC_015572:2531360-2531650 [Methylomonas methanica MC09]
MLKIHTQALAKQDLKNIWLYSFNNWGEVQADRYFDELNAAFALIAENPELGFACDYIREGYRQFHINRHLVFYRVTATKI
HIVRVLHDSMNYTAHL

Nucleotide

• Length: 291 bp

>T25287 NC_015572:2531360-2531650 [Methylomonas methanica MC09]
ATGCTCAAAATCCATACTCAGGCACTCGCAAAACAAGACCTAAAAAATATCTGGCTTTACTCGTTTAACAACTGGGGAGA
GGTGCAGGCGGATCGTTATTTTGATGAATTAAATGCTGCTTTCGCTTTAATCGCTGAAAATCCGGAACTGGGTTTTGCCT
GTGATTACATTCGTGAAGGGTACAGGCAATTCCACATCAATCGCCATTTAGTTTTTTATCGTGTTACAGCAACCAAGATT
CACATTGTCCGGGTGCTACATGACAGTATGAATTACACTGCACATTTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9600.84 Da
• Isoelectric Point: 4.8783

>AT25287 WP_013818957.1 NC_015572:2531097-2531357 [Methylomonas methanica MC09]
MAQARTQTVSLGEHWNNLIDSLLKSGRYASVSEIMRDSLRLLEEREANSKLQSLRTALMEGEESGDAGELHMETIRLEAK
KEAGLV

Nucleotide

• Length: 261 bp

>AT25287 NC_015572:2531097-2531357 [Methylomonas methanica MC09]
ATGGCTCAAGCACGAACCCAAACTGTTAGTCTCGGCGAGCACTGGAATAACCTCATTGACTCTTTGCTCAAAAGTGGGCG
CTATGCAAGCGTTAGTGAAATTATGCGTGACTCCTTACGTTTACTTGAAGAAAGAGAAGCGAACTCAAAACTACAATCTT
TACGTACTGCCCTAATGGAAGGCGAAGAGAGTGGCGATGCTGGCGAATTACACATGGAAACAATCAGATTGGAAGCAAAA
AAAGAAGCCGGTTTAGTCTGA

Structures

Toxin

• AlphaFold DB: F9ZVA8

Antitoxin

• AlphaFold DB: F9ZVA7