252869

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2397069..2397585 Replicon chromosome
Accession NZ_CP101907
Organism Salmonella enterica subsp. enterica strain QA-1986 973

Toxin (Protein)


Gene name relE Uniprot ID A0A7U1KST9
Locus tag NP441_RS11785 Protein ID WP_000220585.1
Coordinates 2397069..2397353 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U1KSR8
Locus tag NP441_RS11790 Protein ID WP_000212721.1
Coordinates 2397343..2397585 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP441_RS11770 (2392185) 2392185..2393837 + 1653 WP_023993572.1 alpha,alpha-phosphotrehalase -
NP441_RS11775 (2394246) 2394246..2396384 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NP441_RS11780 (2396601) 2396601..2397065 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NP441_RS11785 (2397069) 2397069..2397353 - 285 WP_000220585.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP441_RS11790 (2397343) 2397343..2397585 - 243 WP_000212721.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NP441_RS11795 (2397663) 2397663..2399576 - 1914 WP_001212145.1 BglG family transcription antiterminator -
NP441_RS11800 (2399593) 2399593..2400333 - 741 WP_023229489.1 KDGP aldolase family protein -
NP441_RS11805 (2400330) 2400330..2401448 - 1119 WP_023256352.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NP441_RS11810 (2401432) 2401432..2402565 - 1134 WP_023257225.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10878.69 Da        Isoelectric Point: 9.8739

>T252869 WP_000220585.1 NZ_CP101907:c2397353-2397069 [Salmonella enterica subsp. enterica]
MTYELEIDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8995.36 Da        Isoelectric Point: 5.0651

>AT252869 WP_000212721.1 NZ_CP101907:c2397585-2397343 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTFSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U1KST9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U1KSR8

References