Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2355090..2355640 Replicon chromosome
Accession NZ_CP101907
Organism Salmonella enterica subsp. enterica strain QA-1986 973

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag NP441_RS11570 Protein ID WP_001199743.1
Coordinates 2355090..2355398 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag NP441_RS11575 Protein ID WP_001118105.1
Coordinates 2355401..2355640 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP441_RS11555 (2353114) 2353114..2353893 - 780 WP_058653113.1 HNH endonuclease -
NP441_RS11560 (2354054) 2354054..2354368 + 315 WP_058653112.1 hypothetical protein -
NP441_RS11565 (2354365) 2354365..2354654 - 290 Protein_2259 Arm DNA-binding domain-containing protein -
NP441_RS11570 (2355090) 2355090..2355398 - 309 WP_001199743.1 CcdB family protein Toxin
NP441_RS11575 (2355401) 2355401..2355640 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NP441_RS11580 (2355749) 2355749..2355997 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
NP441_RS11585 (2356074) 2356074..2356382 - 309 Protein_2263 DUF4942 domain-containing protein -
NP441_RS11590 (2356402) 2356402..2357379 - 978 WP_223156503.1 IS630 family transposase -
NP441_RS11600 (2358137) 2358137..2359156 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
NP441_RS11605 (2359184) 2359184..2359714 - 531 WP_000896756.1 gluconokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2356402..2357334 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T252868 WP_001199743.1 NZ_CP101907:c2355398-2355090 [Salmonella enterica subsp. enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT252868 WP_001118105.1 NZ_CP101907:c2355640-2355401 [Salmonella enterica subsp. enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References