Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1690461..1691081 Replicon chromosome
Accession NZ_CP101907
Organism Salmonella enterica subsp. enterica strain QA-1986 973

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NP441_RS08585 Protein ID WP_001280991.1
Coordinates 1690863..1691081 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NP441_RS08580 Protein ID WP_000344807.1
Coordinates 1690461..1690835 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP441_RS08570 (1685600) 1685600..1686793 + 1194 WP_001039200.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NP441_RS08575 (1686816) 1686816..1689965 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NP441_RS08580 (1690461) 1690461..1690835 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NP441_RS08585 (1690863) 1690863..1691081 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NP441_RS08590 (1691260) 1691260..1691811 + 552 WP_001278792.1 maltose O-acetyltransferase -
NP441_RS08595 (1691928) 1691928..1692398 + 471 WP_000136181.1 YlaC family protein -
NP441_RS08600 (1692454) 1692454..1692594 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NP441_RS08605 (1692600) 1692600..1692860 - 261 WP_000801421.1 type B 50S ribosomal protein L31 -
NP441_RS08610 (1693085) 1693085..1694635 + 1551 WP_000213145.1 EAL domain-containing protein -
NP441_RS08620 (1694866) 1694866..1695255 + 390 WP_000961285.1 MGMT family protein -
NP441_RS08625 (1695288) 1695288..1695857 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T252866 WP_001280991.1 NZ_CP101907:1690863-1691081 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT252866 WP_000344807.1 NZ_CP101907:1690461-1690835 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References